Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis.

ABSTRACT: In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li-Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished. No melanomas have been reported in any P53-modified mouse models either. In this study, we show that targeted disruption of P53 at the DNA-binding domain in Xenopus tropicalis recapitulates LFS, with the formation of soft-tissue sarcomas and pancreatic ductal adenocarcinoma. Interestingly, 19% of the 14-month-old tp53^Δ7/Δ7 homozygotes and 18% of tp53^+/Δ7 heterozygotes spontaneously developed small nevi and non-invasive melanomas. Large invasive melanomas were also observed in other older homozygous mutants, with about 7.9% penetrance. Our data suggest that more dermatol

SUBMITTER: Ran R 

PROVIDER: S-EPMC9533689 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature