SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses^1-3. In rare cases, viral proteins dampen antiviral responses by mimicking critical regions of human histone proteins^4-8, particularly those containing post-translational modifications required for transcriptional regulation^9-11. Recent work has demonstrated that SARS-CoV-2 markedly disrupts host cell epigenetic regulation^12-14. However, how SARS-CoV-2 controls the host cell epigenome and whether it uses histone mimicry to do so remain unclear. Here we show that the SARS-CoV-2 protein encoded by ORF8 (ORF8

SUBMITTER: Kee J 

PROVIDER: S-EPMC9533993 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature