Long-Term Oncological Outcomes After Colorectal Anastomotic Leakage: A Retrospective Dutch Population-based Study.

ABSTRACT:

Objective

The aim was to evaluate the impact of anastomotic leak (AL) after colon cancer (CC) and rectal cancer (RC) surgery on 5-year relative survival, disease-free survival (DFS), and disease recurrence.

Background

AL after CC and RC resection is a severe postoperative complication with conflicting evidence whether it deteriorates long-term outcomes.

Methods

Patients with stage I to IV CC and RC who underwent resection with primary anastomosis were included from the Netherlands Cancer Registry (2008-2018). Relative survival, measured from day of resection, and multivariable relative excess risks (RERs) were analyzed. DFS and recurrence were evaluated in a subset with stage I to III patients operated in 2015. All analyses were performed with patients who survived 90

SUBMITTER: Arron MNN 

PROVIDER: S-EPMC9534056 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature