Monkeypox outbreak in Madrid (Spain): Clinical and virological aspects.

ABSTRACT:

Background

Monkeypox is the most prevalent Orthopoxvirus zoonosis infection since the eradication of smallpox. The current multi-country outbreak involves five WHO regions affecting mainly Europe. Accurate clinical and virological aspects of the disease outside endemic areas are needed.

Methods

We performed an observational study of cases diagnosed in Madrid (Spain) (May/June 2022). Confirmation from vesicular lesions swabs, Orthopoxvirus real-time PCR, sequencing, phylogenetic analysis, and direct detection by Electron microscopy was performed. In addition, a structured epidemiological questionnaire was completed systematically to gather sociodemographic, clinical, and behavioral data from all confirmed cases.

Findings

We extracted data from 48 patients, all cisgende

SUBMITTER: Orviz E 

PROVIDER: S-EPMC9534097 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature