The 2022 Monkeypox outbreak: How the medicinal chemistry could help us?

ABSTRACT: Monkeypox disease is a zoonosis that has the monkey virus (MPXV) as its etiologic agent, an enveloped double-stranded DNA virus that has caused some severe cases, leading to 3-6% fatality ratio. MPXV exhibits similar symptoms to those observed for Smallpox infection. Human-to-human transmission occurs via droplet respiratory particles and close contact with skin lesions of an infected person or recently contaminated objects. MPXV symptoms include fever, intense headache, back pain, myalgia, severe asthenia, lymphadenopathy, and skin eruption. The 2022 outbreak is growing, spreading over 75 countries/territories. Based on this, the MPXV outbreak was declared a "public health emergency of international concern" by WHO. In 2019, a vaccine-based modified attenuated vaccinia virus (Ankara strai

SUBMITTER: Silva-Junior EFD 

PROVIDER: S-EPMC9534107 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature