Thionitrite and Perthionitrite in NO Signaling at Zinc.

ABSTRACT: NO and H₂ S serve as signaling molecules in biology with intertwined reactivity. HSNO and HSSNO with their conjugate bases ^- SNO and ^- SSNO form in the reaction of H₂ S with NO as well as S-nitrosothiols (RSNO) and nitrite (NO₂ ^- ) that serve as NO reservoirs. While HSNO and HSSNO are elusive, their conjugate bases form isolable zinc complexes ^Ph,Me TpZn(SNO) and ^Ph,Me TpZn(SSNO) supported by tris(pyrazolyl)borate ligands. Reaction of Na(15-C-5)SSNO with ^Ph,Me TpZn(ClO₄ ) provides ^Ph,Me TpZn(SSNO) that undergoes S-atom removal by PEt₃ to give ^Ph,Me TpZn(SNO) and S=PEt₃ . Unexpectedly stable at room temperature, these Zn-SNO and Zn-SSNO co

SUBMITTER: Hosseininasab V 

PROVIDER: S-EPMC9534351 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature