Statistical methodologies for evaluation of the rate of persistence of Ebola virus in semen of male survivors in Sierra Leone

ABSTRACT: The 2013–2016 Ebola virus (EBOV) outbreak in West Africa was the largest and most complex outbreak ever, with a total number of cases and deaths higher than in all previous EBOV outbreaks combined. The outbreak was characterized by rapid spread of the infection in nations that were weakly prepared to handle it. EBOV ribonucleic acid (RNA) is known to persist in body fluids following disease recovery, and studying this persistence is crucial for controlling such epidemics. Observational cohort studies investigating EBOV persistence in semen require following up recently recovered survivors of Ebola virus disease (EVD), from recruitment to the time when their semen tests negative for EBOV, the endpoint being time-to-event. Because recruitment of EVD survivors takes place weeks or months foll

SUBMITTER: Habib N 

PROVIDER: S-EPMC9534448 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature