HMGB1 is a mediator of cuproptosis-related sterile inflammation.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC9534480 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
HMGB1 is a mediator of cuproptosis-related sterile inflammation.
Liu Jiao J Liu Yang Y Wang Yuan Y Kang Rui R Tang Daolin D
Frontiers in cell and developmental biology 20220921
Cuproptosis is a recently recognized modality of cell death driven by intracellular copper-dependent mitochondrial stress. However, the mediators of the sterile inflammatory response to cuproptotic death are undetermined. Here, we report that high-mobility group box 1 (HMGB1), a damage-associated molecular pattern, is released by cuproptotic cells to initiate inflammation. Mechanically, copper accumulation-induced adenosine triphosphate (ATP) depletion activates AMP-activated protein kinase (AMP ...[more]
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2023-04-30 | E-MTAB-11980 | biostudies-arrayexpress
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