Effects of Genetic Variants in the Nicotine Metabolism Pathway on Smoking Cessation.

ABSTRACT:

Background

We aimed to investigate the associations of various genetic variants in the nicotine metabolism pathway with smoking cessation (SC) in the Chinese Han population.

Method

A case-control study was conducted where 363 successful smoking quitters were referred to as cases, and 345 failed smoking quitters were referred to as controls. A total of 42 genetic variants in 10 genes were selectedand genotyped. The weighted gene score was applied to analyze the whole gene effect. Logistic regression was used to explore associations of each genetic variant and gene score with smoking cessation.

Results

Our study found that the variants CYP2A6∗4, rs11726322, rs12233719, and rs3100 were associated with a higher probability of quitting smoking, while rs3760657 was a

SUBMITTER: Li H 

PROVIDER: S-EPMC9534651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature