Embryo model completes gastrulation to neurulation and organogenesis.

ABSTRACT: Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro^1-5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembryonic endoderm stem (XEN) cells and inducible XEN (iXEN) cells^6-11. Here we assembled stem cell-derived embryos in vitro from mouse ES cells, TS cells and iXEN cells and showed that they recapitulate the development of whole natural mouse embryo in utero up to day 8.5 post-fertilization. Our embryo model displays headfolds with defined forebrain and midbrain regions and develops a beating heart-like structure, a trunk comprising a neural tube and somites, a tail bud containing neuromesodermal progenitors, a gut tube, and prim

SUBMITTER: Amadei G 

PROVIDER: S-EPMC9534772 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature