A novel role of follicle-stimulating hormone (FSH) in various regeneration-related functions of endometrial stem cells.

ABSTRACT: Follicle-stimulating hormone (FSH) promotes the production and secretion of estrogen, which in turn stimulates the growth and maturation of ovarian follicles. Therefore, consecutive FSH treatment to induce ovarian hyperstimulation (superovulation) is still considered the most cost-effective option for the majority of assisted reproductive technologies (ARTs). However, a relatively high cancellation rate and subsequent low pregnancy outcomes (approximately 15%) are the most challenging aspects of this FSH-based ART. Currently, the main cause for this low implantation rate of FSH-based ART has not yet been revealed. Therefore, we hypothesized that these high cancellation rates with FSH-based superovulation protocols might be associated with the harmful effects of consecutive FSH treatment. I

SUBMITTER: Park SR 

PROVIDER: S-EPMC9534881 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature