Antidepressant use and risk of adverse outcomes: population-based cohort study.

ABSTRACT:

Background

Antidepressants are one of the most widely prescribed drugs in the global north. However, little is known about the health consequences of long-term treatment.

Aims

This study aimed to investigate the association between antidepressant use and adverse events.

Method

The study cohort consisted of UK Biobank participants whose data was linked to primary care records (N = 222 121). We assessed the association between antidepressant use by drug class (selective serotonin reuptake inhibitors (SSRIs) and 'other') and four morbidity (diabetes, hypertension, coronary heart disease (CHD), cerebrovascular disease (CV)) and two mortality (cardiovascular disease (CVD) and all-cause) outcomes, using Cox's proportional hazards model at 5- and 10-year follow-up.

SUBMITTER: Bansal N 

PROVIDER: S-EPMC9534882 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature