Effects of psilocybin versus escitalopram on rumination and thought suppression in depression.

ABSTRACT:

Background

Major depressive disorder is often associated with maladaptive coping strategies, including rumination and thought suppression.

Aims

To assess the comparative effect of the selective serotonin reuptake inhibitor escitalopram, and the serotonergic psychedelic psilocybin (COMP360), on rumination and thought suppression in major depressive disorder.

Method

Based on data derived from a randomised clinical trial (N = 59), we performed exploratory analyses on the impact of escitalopram versus psilocybin (i.e. condition) on rumination and thought suppression from 1 week before to 6 weeks after treatment inception (i.e. time), using mixed analysis of variance. Condition responder versus non-responder subgroup analyses were also done, using the standard defin

SUBMITTER: Barba T 

PROVIDER: S-EPMC9534928 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature