Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.

ABSTRACT: Mitochondria in neural progenitors play a crucial role in adult hippocampal neurogenesis by being involved in fate decisions for differentiation. However, the molecular mechanisms by which mitochondria are related to the genetic regulation of neuronal differentiation in neural progenitors are poorly understood. Here, we show that mitochondrial dysfunction induced by amyloid-beta (Aβ) in neural progenitors inhibits neuronal differentiation but has no effect on the neural progenitor stage. In line with the phenotypes shown in Alzheimer's disease (AD) model mice, Aβ-induced mitochondrial damage in neural progenitors results in deficits in adult hippocampal neurogenesis and cognitive function. Based on hippocampal proteome changes after mitochondrial damage in neural progenitors identified thr

SUBMITTER: Kim DK 

PROVIDER: S-EPMC9534996 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature