P(v-a)CO₂/C(a-v)O₂ as a red blood cell transfusion trigger and prognostic indicator for sepsis-related anaemia: protocol for a prospective cohort study.

ABSTRACT:

Introduction

Red blood cell (RBC) transfusion primarily aims to improve oxygen transport and tissue oxygenation. The transfusion strategy based on haemoglobin concentration could not accurately reflect cellular metabolism. The ratio of venous-arterial carbon dioxide tension difference to arterial-venous oxygen content difference (P(v-a)CO₂/C(a-v)O₂) is a good indicator of cellular hypoxia. We aim to explore the influence of P(v-a)CO₂/C(a-v)O₂ as an RBC transfusion trigger on outcomes in septic shock patients.

Methods and analysis

The study is a single-centre prospective cohort study. We consecutively enrol adult septic shock patients requiring RBC transfusion at intensive care unit (ICU) admission or during ICU stay. P(v-a)CO₂

SUBMITTER: Gu WJ 

PROVIDER: S-EPMC9535211 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature