Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial.

ABSTRACT: Postdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential anticancer effects, but these remain poorly explored in clinical settings. The objective of this study was to explore the effects of a single exercise bout on tumor oxygenation and immune cell infiltration in patients with prostate cancer. Thirty patients with localized prostate cancer were randomized (2:1) to either one high-intensity interval training bout or no exercise on the day before radical prostatectomy. Immunohistochemical analyses were performed on prostatic tissue from surgery and assessed for tumor hypoxia, natural killer (NK) cell infiltrat

SUBMITTER: Djurhuus SS 

PROVIDER: S-EPMC9535256 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature