Recreational physical activity before and during pregnancy and placental DNA methylation-an epigenome-wide association study.

ABSTRACT:

Background

Physical activity (PA) prior to and during pregnancy may have intergenerational effects on offspring health through placental epigenetic modifications. We are unaware of epidemiologic studies on longitudinal PA and placental DNA methylation.

Objectives

We evaluated the association between PA before and during pregnancy and placental DNA methylation.

Methods

Placental tissues were obtained at delivery and methylation was measured using HumanMethylation450 Beadchips for participants in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singletons among 298 participants. Using the Pregnancy Physical Activity Questionnaire, women recalled periconception PA (past 12 mo) at 8-13 wk of gestation and PA since la

SUBMITTER: Zhao SK 

PROVIDER: S-EPMC9535520 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature