Body composition trajectories from birth to 5 years and hepatic fat in early childhood.

ABSTRACT:

Background

Adiposity is an established risk factor for pediatric nonalcoholic fatty liver disease (NAFLD), but little is known about the influence of body composition patterns earlier in life on NAFLD risk.

Objectives

We aimed to examine associations of body composition at birth and body composition trajectories from birth to early childhood with hepatic fat in early childhood.

Methods

Data were from the longitudinal Healthy Start Study in Colorado. Fat-free mass index (FFMI), fat mass index (FMI), percentage body fat (BF%), and BMI were assessed at birth and/or ∼5 y in >1200 children by air displacement plethysmography and anthropometrics. In a subset (n = 285), hepatic fat was also assessed at ∼5 y by MRI. We used a 2-stage modeling approach: first, we fit body comp

SUBMITTER: Cohen CC 

PROVIDER: S-EPMC9535524 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature