Establishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson's Disease and Pink1 Knockout Rats.

ABSTRACT:

Background

Rodent Parkinson's disease (PD) models are valuable to interrogate neurobiological mechanisms of exercise that mitigate motor impairment. Translating these mechanisms to human PD must account for physical capabilities of the patient.

Objective

To establish cardiovascular parameters as a common metric for cross-species translation of aerobic exercise impact.

Method

We evaluated aerobic exercise impact on heart rate (HR) in 21 early-stage PD subjects (Hoehn Yahr ≤1.5) exercising in non-contact boxing training for ≥3 months, ≥3x/week. In 4-month-old Pink1 knockout (KO) rats exercising in a progressively-increased treadmill speed regimen, we determined a specific treadmill speed that increased HR to an extent similar in human subjects.

Results

After comp

SUBMITTER: Salvatore MF 

PROVIDER: S-EPMC9535586 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature