Sex, Neuropsychiatric Profiles, and Caregiver Burden in Alzheimer's Disease Dementia: A Latent Class Analysis.

ABSTRACT:

Background

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) can be disruptive for patients and their families.

Objective

We aimed to classify patients based on NPS and to explore the relationship of these classes with sex and with caregiver burden.

Methods

The study cohort comprised individuals with AD dementia diagnosed at Ace Alzheimer Center in Barcelona, Spain, between 2011-2020. NPS were ascertained by using the Neuropsychiatric Inventory-Questionnaire. Latent class analysis was used to identify clusters of individuals sharing a similar NPS profile. We evaluated the caregiver burden using the Zarit Burden Interview. Multivariable regression models were used to obtain adjusted estimates of the association between sex, NPS classes, and caregiver burden.<

SUBMITTER: Rosende-Roca M 

PROVIDER: S-EPMC9535594 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature