Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.

ABSTRACT:

Objectives

To better understand the temporal dynamics of progression from cognitive decline to onset of dementia in the dementia-free older population in the United States.

Methods

We used longitudinal data from a diverse national population-based sample of older adults (N = 531) in the Aging, Demographics, and Memory Study from the Health and Retirement Study with repeated measures of cognitive function and dementia diagnosis during 12 years of follow-up from 1996 to 2009. We employed joint latent class mixed models to estimate the association between cognitive change and competing risks of dementia and nondementia death and identify heterogeneity in the age profiles of such association adjusting for baseline characteristics.

Results

Our analyses found 3 latent class

SUBMITTER: Walsh CE 

PROVIDER: S-EPMC9535777 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature