Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias.

ABSTRACT:

Background

Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and is modulated by inflammation in the brain. Previously, we found sex differences in the activation of the amygdala and the hippocampus in response to negative cognitive bias in rats that varied with age. Given the association of cognitive bias to neurogenesis and inflammation, we examined associations between cognitive bias, neurogenesis in the hippocampus, and cytokine and chemokine levels in the ventral hippocampus (HPC) and basolateral amygdala (BLA) of male and female rats across the lifespan.

Results

After cognitive bias testing, males had more IFN-γ, IL

SUBMITTER: Hodges TE 

PROVIDER: S-EPMC9535862 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature