A novel nuclear receptor subfamily enlightens the origin of heterodimerization.

ABSTRACT:

Background

Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from functional studies undertaken in classical model animals. It has become evident, however, that a deeper understanding of these molecular functions requires uncovering how these characteristics originated and diversified during evolution, by looking at more species. In particular, the comprehension of how dimerization evolved from ancestral homodimers to a more sophisticated state of heterodimers has been missing, due to a too narrow phylogenetic sampling. Here, we experimentally and phylogenetically define the evolutionary trajectory of nuclear recep

SUBMITTER: Beinsteiner B 

PROVIDER: S-EPMC9535869 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature