Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus.

ABSTRACT:

Background

Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown.

Results

We report the first study of AF1 function in mice. The AF1 mutant mice are infertile with impaired implantation and decidualization. This is associated with a delay in the cessation of epithelial proliferation and in the initiation of stromal proliferation at preimplantation. Despite tissue selective effect on PGR target genes, AF1 mutations caused global loss of the antioestrogenic activity of progesterone in both pregnant and ovariectomized models. Importantly, the study provides evidence that PG

SUBMITTER: Lee SH 

PROVIDER: S-EPMC9535881 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature