Genetic association of ANGPT2 with primary open-angle glaucoma.

ABSTRACT:

Background

To determine the association of the ANGPT2 gene with primary open-angle glaucoma (POAG) in Chinese.

Methods

Six single-nucleotide polymorphisms (SNPs) in ANGPT2 (rs2515487, rs2922869, rs13255574, rs4455855, rs13269021, and rs11775442) were genotyped in a total of 2601 study subjects from two cohorts. One is a Hong Kong Chinese cohort of 484 high tension glaucoma (HTG) and 537 normal tension glaucoma (NTG) patients, and 496 non-glaucoma control subjects. Another cohort is a Shantou Chinese cohort of 403 HTG and 135 NTG patients, and 543 non-glaucoma control subjects. Subgroup analysis by sex was conducted. Outcomes from different cohorts were combined for meta-analysis.

Results

The association of SNP rs11775442 with NTG in the Hong Kong cohort [P = 0.0498, O

SUBMITTER: He JN 

PROVIDER: S-EPMC9535884 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature