Glycosylated haemoglobin and prognosis in 10,536 people with cancer and pre-existing diabetes: a meta-analysis with dose-response analysis.

ABSTRACT:

Aims

To assess whether glycaemic control is associated with prognosis in people with cancer and pre-existing diabetes.

Methods

In this pre-registered systematic review (PROSPERO: CRD42020223956), PubMed and Web of Science were searched on 25th Nov 2021 for studies investigating associations between glycosylated haemoglobin (HbA_1c) and prognosis in people with diabetes and cancer. Summary relative risks (RRs) and 95% Confidence Intervals (CIs) for associations between poorly controlled HbA_1c or per 1-unit HbA_1c increment and cancer outcomes were estimated using a random-effects meta-analysis. We also investigated the impact of potential small-study effects using the trim-and-fill method and potential sources of heterogeneity using subgroup ana

SUBMITTER: Ling S 

PROVIDER: S-EPMC9535893 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature