Salivary microbiome in children with Down syndrome: a case-control study.

ABSTRACT:

Background

Down syndrome (DS), a most frequently occurring genetic disorder, is associated with oral morphological abnormalities and higher incidence rates of oral diseases. Recent studies have analyzed the oral microbiome to elucidate their relationships with oral diseases and general health; however, reports on the oral microbiome in individuals with DS are scarce. This study aimed to characterize the oral microbiome in children with DS.

Methods

A total of 54 children aged 1-13 years were enrolled in this case-control study. Of these children, 27 had DS (Case: DS group) and 27 were age-matched healthy children (Control: ND group). Saliva in the oral cavity was collected with a swab, cultured, and tested for cariogenic and periodontopathic bacteria by quantitative polymeras

SUBMITTER: Morishima S 

PROVIDER: S-EPMC9535924 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature