Preclinical assessment of onabotulinumtoxinA for the treatment of mild traumatic brain injury-related acute and persistent post-traumatic headache.

ABSTRACT:

Objective

Investigation of onabotulinumtoxinA in a murine model of acute and persistent post-traumatic headache.

Methods

Mild traumatic brain injury was induced with a weight drop method. Periorbital and hindpaw cutaneous allodynia were measured for 14 days. Mice were then exposed to bright light stress and allodynia was reassessed. OnabotulinumtoxinA (0.5 U) was injected subcutaneously over the cranial sutures at different post-injury time points.

Results

After milt traumatic brain injury, mice exhibited periorbital and hindpaw allodynia that lasted for approximately 14 days. Allodynia could be reinstated on days 14-67 by exposure to stress only in previously injured mice. OnabotulinumtoxinA administration at 2 h after mild traumatic brain injury fully blocked both t

SUBMITTER: Navratilova E 

PROVIDER: S-EPMC9535972 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature