Clinical prediction models assessing response to radiotherapy for rectal cancer: protocol for a systematic review

ABSTRACT:

Background

Rectal cancer has a high prevalence. The standard of care for management of localised disease involves major surgery and/or chemoradiotherapy, but these modalities are sometimes associated with mortality and morbidity. The notion of ‘watch and wait’ has therefore emerged and offers an organ-sparing approach to patients after administering a less invasive initial treatment, such as X-ray brachytherapy (Papillon technique). It is thus important to evaluate how likely patients are to respond to such therapies, to develop patient-tailored treatment pathways. We propose a systematic review to identify published clinical prediction models of the response of rectal cancer to treatment that includes radiotherapy and here present our protocol.

Methods

Included studies w

SUBMITTER: Karageorgou M 

PROVIDER: S-EPMC9535989 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature