Periviscerokinin (Cap_2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output.

ABSTRACT:

Background

The cattle fever tick, Rhipicephalus (Boophilus) microplus, is a vector of pathogens causative of babesiosis and anaplasmosis, both highly lethal bovine diseases that affect cattle worldwide. In Ecdysozoa, neuropeptides and their G-protein-coupled receptors play a critical integrative role in the regulation of all physiological processes. However, the physiological activity of many neuropeptides is still unknown in ticks. Periviscerokinins (CAP_2b/PVKs) are neuropeptides associated with myotropic and diuretic activities in insects. These peptides have been identified only in a few tick species, such as Ixodes ricinus, Ixodes scapularis and R. microplus, and their cognate receptor only characterized for the last two.

Methods

Expression of the periviscerok

SUBMITTER: Wulff JP 

PROVIDER: S-EPMC9535995 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature