Depth-profile of impairments in endothelin-1 - induced focal cortical ischemia.

ABSTRACT: The development of ischemic lesions has primarily been studied in horizontal cortical space. However, how ischemic lesions develop through the cortical depth remains largely unknown. We explored this question using direct current coupled recordings at different cortical depths using linear arrays of iridium electrodes in the focal epipial endothelin-1 (ET1) ischemia model in the rat barrel cortex. ET1-induced impairments were characterized by a vertical gradient with (i) rapid suppression of the spontaneous activity in the superficial cortical layers at the onset of ischemia, (ii) compartmentalization of spreading depolarizations (SDs) to the deep layers during progression of ischemia, and (iii) deeper suppression of activity and larger histological lesion size in superficial cortical laye

SUBMITTER: Vinokurova D 

PROVIDER: S-EPMC9536115 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature