Validation, kinetic modeling, and test-retest reproducibility of [¹⁸F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice.

ABSTRACT: Alterations in synaptic vesicle glycoprotein 2 A (SV2A) have been associated with several neuropsychiatric and neurodegenerative disorders. Therefore, SV2A positron emission tomography (PET) imaging may provide a unique tool to investigate synaptic density dynamics during disease progression and after therapeutic intervention. This study aims to extensively characterize the novel radioligand [¹⁸F]SynVesT-1 for preclinical applications. In C57Bl/6J mice (n = 39), we assessed the plasma profile of [¹⁸F]SynVesT-1, validated the use of a noninvasive image-derived input function (IDIF) compared to an arterial input function (AIF), performed a blocking study with levetiracetam (50 and 200 mg/kg, i.p.) to verify the specificity towards SV2A, examined kinetic models fo

SUBMITTER: Bertoglio D 

PROVIDER: S-EPMC9536120 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature