Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.

ABSTRACT: Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic changes correspond with activation of NF-κB signaling, extracellular matrix remodeling, increased integrin αvβ3 expression, and ETS family transcription factor binding. Here, we characterize these changes in vitro, in vivo, and in a data set of human OS patients. This increased aggression substantially sensitizes ATRX-deficient OS cells to integrin signaling inhibition. Thus, ATRX plays an important tumor-suppression role in OS, and loss of function of this gene may underlie new therapeutic vulnerabilities. The relationship between ATRX

SUBMITTER: Bartholf DeWitt S 

PROVIDER: S-EPMC9536280 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature