Urethral Melanoma - Clinical, Pathological and Molecular Characteristics.

ABSTRACT:

Background

Mucosal melanoma involving the urethra is a rare disease with distinct clinical and molecular characteristics and poor outcomes. Our current knowledge is limited by the small number of reports regarding this disease.

Objective

To describe the clinical, pathological, and molecular characteristics of urethral melanoma.

Methods

We summarized the clinicopathologic data for 31 patients treated for urethral melanoma from 1986-2017 at our institution. Genomic data from our institutional sequencing platform MSK-IMPACT (n = 5) and gene-specific PCR data on BRAF, KIT, and/or NRAS (n = 8) were compared to genomic data of cutaneous melanomas (n = 143), vulvar/vaginal melanomas (n = 24), and primary non-melanoma urethral

SUBMITTER: Mano R 

PROVIDER: S-EPMC9536426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature