The Association of Prior Intensive Lifestyle Intervention and Diabetes Support and Education With Frailty Prevalence at Long-Term Follow-Up in the Action for Health in Diabetes Extension Study.

ABSTRACT:

Background

Frailty is common in older adults with obesity and diabetes. We compared prevalence of the frailty phenotype between intervention groups in long-term follow-up of Look Action for Health in Diabetes Study (AHEAD), a randomized trial comparing a multidomain intensive lifestyle intervention (ILI) that promoted weight loss and physical activity with a diabetes support and education (DSE) control group in adults with type 2 diabetes and overweight or obesity.

Method

Participants included 2 979 individuals randomized to ILI or DSE in 2001-2004 who completed frailty assessment in Look AHEAD-Extension Wave 1 (2016-2018) at an average age of 72.1 ± 6.2 years. Frailty was assessed using a modified frailty phenotype definition (excluding weight loss) defined as the presence

SUBMITTER: Look AHEAD Research Group 

PROVIDER: S-EPMC9536442 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature