Automated Solid Phase Assisted Synthesis of a Heparan Sulfate Disaccharide Library.

ABSTRACT: Heparan sulfate (HS) regulates a wide range of biological events, including blood coagulation, cancer development, cell differentiation, and viral infections. It is generally recognized that structures of HS can critically impact its biological functions. However, with complex structures of naturally existing HS, systematic investigations into the structure-activity relationship (SAR) of HS and efforts to unlock their "sulfation code" have been largely limited due to the challenges in preparing diverse HS oligosaccharide sequences. Herein, we report an automated machine-aided solid-phase strategy that significantly expedited the assembly of HS disaccharides. The key strategically protected advanced disaccharide intermediates were immobilized onto Synphase lanterns. Divergent deprotections

SUBMITTER: Ramadan S 

PROVIDER: S-EPMC9536483 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature