GSDM gene polymorphisms regulate the IgE level in asthmatic patients.

ABSTRACT:

Background

Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients.

Objective

In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) in Jordanian population were investigated for their association with total IgE levels in serum of asthmatic children and adult subjects.

Methods

The genetic polymorphism analys

SUBMITTER: Imraish A 

PROVIDER: S-EPMC9536611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature