⁶⁸Ga-Citrate PET of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates.

ABSTRACT: ⁶⁸Ga-citrate has one of the simplest chemical structures of all ⁶⁸Ga-radiopharmaceuticals, and its clinical use is justified by the proven medical applications using its isotope-labeled compound ⁶⁷Ga-citrate. To support broader application of ⁶⁸Ga-citrate in medical diagnosis, further research is needed to gain clinical data from healthy volunteers. In this work, we studied the biodistribution of ⁶⁸Ga-citrate and subsequent radiation exposure from it in healthy men. Methods: ⁶⁸Ga-citrate was prepared with an acetone-based radiolabeling procedure compliant with good manufacturing practices. Six healthy men (age 41 ± 12 y, mean ± SD) underwent sequential whole-body PET/CT scans after an injection of 204 ± 8 MBq of

SUBMITTER: Suilamo S 

PROVIDER: S-EPMC9536698 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature