Mendelian randomization analysis reveals causal effects of food intakes on inflammatory bowel disease risk.

ABSTRACT: Traditional observational studies have indicated a link between specific food intakes and inflammatory bowel disease (IBD), but the nature of such links remains unknown. We sought to assess the potential causal relationship between food intakes and IBD risk using Mendelian randomization methods. This study used summary statistics data from large-scale genome-wide association studies (GWAS) on food intakes, Crohn's disease (CD), and ulcerative colitis (UC). In the primary analysis, we used the inverse variance-weighted method to determine whether specific food was causal for CD and UC. In addition, we also ran four other Mendelian randomization methods, including MR Egger, weighted median, maximum likelihood, and weighted mode as a complement. The primary analysis showed that high consumpti

SUBMITTER: Chen B 

PROVIDER: S-EPMC9536736 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature