Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model.
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ABSTRACT:
SUBMITTER: Schmitt K
PROVIDER: S-EPMC9536748 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model.
Schmitt Kimberly K Curlin James J Remling-Mulder Leila L Morrison Jared J Moriarty Ryan R Goff Kelly K Stenglein Mark M O'Connor Shelby S Marx Preston P Akkina Ramesh R
Journal of medical primatology 20220828 5
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4<sup>+</sup> T-cell decline, and nonsynonymous substitutions arose suggesting viral evolution. ...[more]
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