Regulation of protein abundance in genetically diverse mouse populations.
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ABSTRACT:
SUBMITTER: Keele GR
PROVIDER: S-EPMC9536773 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Regulation of protein abundance in genetically diverse mouse populations.
Keele Gregory R GR Zhang Tian T Pham Duy T DT Vincent Matthew M Bell Timothy A TA Hock Pablo P Shaw Ginger D GD Paulo Joao A JA Munger Steven C SC de Villena Fernando Pardo-Manuel FP Ferris Martin T MT Gygi Steven P SP Churchill Gary A GA
Cell genomics 20210903 1
Genetically diverse mouse populations are powerful tools for characterizing the regulation of the proteome and its relationship to whole-organism phenotypes. We used mass spectrometry to profile and quantify the abundance of 6,798 proteins in liver tissue from mice of both sexes across 58 Collaborative Cross (CC) inbred strains. We previously collected liver proteomics data from the related Diversity Outbred (DO) mice and their founder strains. We show concordance across the proteomics datasets ...[more]
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