Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder.

ABSTRACT:

Objective

Considerable evidence suggests that neuroinflammation plays an important role in the pathophysiology of major depressive disorder (MDD). However, the relationship between serum C4 binding protein (C4BP) and white matter (WM) tract integrity in MDD has not been investigated.

Methods

We obtained diffusion tensor images of 44 patients with MDD and 44 healthy controls and performed TRActs Constrained by UnderLying Anatomy (TRACULA) analysis to assess WM tract integrity. Serum C4-binding protein alpha chain (C4BPA) and C4- binding protein beta chain (C4BPB) levels were measured and in-between group comparisons were obtained. The correlation between serum C4BP levels and WM tract integrity was examined.

Results

In comparison to healthy controls, both serum C4BPA a

SUBMITTER: Park J 

PROVIDER: S-EPMC9536885 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature