Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined.
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ABSTRACT: Objective
This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.Methods
Nine patients with Parkinson's disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.Results
In previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.Conclusion
Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.
SUBMITTER: Shin C
PROVIDER: S-EPMC9536904 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined.
Shin Chaewon C Kim Seong-Ik SI Park Sung-Hye SH Shin Jung Hwan JH Lee Chan Young CY Yang Han-Kwang HK Lee Hyuk-Joon HJ Kong Seong-Ho SH Suh Yun-Suhk YS Kim Han-Joon HJ Jeon Beomseok B
Journal of movement disorders 20220726 3
<h4>Objective</h4>This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.<h4>Methods</h4>Nine patients with Parkinson's disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal an ...[more]
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