Semiautomated Algorithm for the Diagnosis of Multiple System Atrophy With Predominant Parkinsonism.

ABSTRACT:

Objective

Putaminal iron deposition is an important feature that helps differentiate multiple system atrophy with predominant parkinsonism (MSA-p) from Parkinson's disease (PD). Most previous studies used visual inspection or quantitative methods with manual manipulation to perform this differentiation. We investigated the value of a new semiautomated diagnostic algorithm using 3T-MR susceptibility-weighted imaging for MSA-p.

Methods

This study included 26 MSA-p, 68 PD, and 41 normal control (NC) subjects. The algorithm was developed in 2 steps: 1) determine the image containing the remarkable putaminal margin and 2) calculate the phase-shift values, which reflect the iron concentration. The next step was to identify the best differentiating conditions among several combinat

SUBMITTER: Lee WW 

PROVIDER: S-EPMC9536910 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature