Potential Link Between Cognition and Motor Reserve in Patients With Parkinson's Disease.

ABSTRACT:

Objective

To investigate whether there is a link between cognitive function and motor reserve (i.e., individual capacity to cope with nigrostriatal dopamine depletion) in patients with newly diagnosed Parkinson's disease (PD).

Methods

A total of 163 patients with drug-naïve PD who underwent 18F-FP-CIT PET, brain MRI, and a detailed neuropsychological test were enrolled. We estimated individual motor reserve based on initial motor deficits and striatal dopamine depletion using a residual model. We performed correlation analyses between motor reserve estimates and cognitive composite scores. Diffusion connectometry analysis was performed to map the white matter fiber tracts, of which fractional anisotropy (FA) values were well correlated with motor reserve estimates. Additiona

SUBMITTER: Chung SJ 

PROVIDER: S-EPMC9536917 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature