LncRNA NEAT1 Promotes Colorectal Cancer Progression by Increasing Inflammation.

ABSTRACT:

Background

Colorectal cancer is a digestive tract malignant tumor, ranking the second mortality and the third incidence cancer worldwide. The abnormal expression of NEAT1 is related to the occurrence and development of colorectal cancer. However, the specific mechanism of NEAT1 mediated-inflammatory pathway in the progression of colorectal cancer is still unclear.

Methods

In this study, expression of NEAT1 in colorectal cancer patients was analyzed by bioinformatics. Clinical samples including peripheral blood and colorectal cancer tissues were collected for qRT-PCR, Western blot, and immunohistochemistry assay. The role of NEAT1 in the colorectal cancer progression was further confirmed by both in-vivo and in-vitro functional experiments.

Results

By bio

SUBMITTER: Chen Q 

PROVIDER: S-EPMC9536976 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature