Identification of Key Gene Targets for Periodontitis Treatment by Bioinformatics Analysis.

ABSTRACT:

Background

Periodontitis is considered to be the leading cause of tooth loss in adults, and it interacts with some serious systemic diseases. Periodontal basic therapy is the cornerstone of periodontal disease treatment and long-term maintenance and has a positive impact on the treatment of systemic diseases.

Aim

To explore the potential gene targets of periodontitis therapies by bioinformatics method.

Methods

We analyzed the expression database (GSE6751) downloaded from the Gene Expression Omnibus (GEO) with weighted gene coexpression network analysis (WGCNA) to confirm the functional gene modules. Pathway enrichment network analyses the key genes in functional modules and verified the candidate genes from the samples in peripheral blood sources of GSE43525. Moreover

SUBMITTER: Jin Y 

PROVIDER: S-EPMC9536999 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature