The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer's disease.

ABSTRACT: Language is usually characterized as the most preserved cognitive function during typical aging. Several neuroimaging studies have shown that healthy aging is characterized by inter-network compensation which correlates with better language performance. On the contrary, language deficits occur early in the course of Alzheimer's disease (AD). Therefore, this study compares young participants, healthy older participants, and prodromal AD participants, to characterize functional connectivity changes in language due to healthy aging or prodromal AD. We first compared measures of integrated local correlations (ILCs) and fractional amplitude of low-frequency oscillations (fALFFs) in language areas. We showed that both groups of older adults had lower connectivity values within frontal language-r

SUBMITTER: Rafiq M 

PROVIDER: S-EPMC9537133 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature