Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.

ABSTRACT: Production of a functional peripheral T cell compartment typically involves massive expansion of the bone marrow progenitors that seed the thymus. There are two main phases of expansion during T cell development, following T lineage commitment of double-negative (DN) 2 cells and after successful rearrangement and selection for functional TCRβ chains in DN3 thymocytes, which promotes the transition of DN4 cells to the DP stage. The signals driving the expansion of DN2 thymocytes are well studied. However, factors regulating the proliferation and survival of DN4 cells remain poorly understood. Here, we uncover an unexpected link between the transcription factor Zfp335 and control of cGAS/STING-dependent cell death in post-β-selection DN4 thymocytes. Zfp335 controls survival by sustaining exp

SUBMITTER: Ratiu JJ 

PROVIDER: S-EPMC9537144 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature