Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency.

ABSTRACT:

Purpose

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency, with heterogeneous clinical presentation. Our goal was to analyze CD8 T cell homeostasis in patients with infection only CVID, compared to those additionally affected by dysregulatory and autoimmune phenomena.

Methods

We used flow and mass cytometry evaluation of peripheral blood of 40 patients with CVID and 17 healthy donors.

Results

CD8 T cells are skewed in patients with CVID, with loss of naïve and increase of effector memory stages, expansion of cell clusters with high functional exhaustion scores, and a highly activated population of cells with immunoregulatory features, producing IL-10. These findings correlate to clinically widely used B cell-based EURO c

SUBMITTER: Klocperk A 

PROVIDER: S-EPMC9537220 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature